The study aims at investigating the cellular mechanisms of action of FLE on key skin and immune cells. FLE serves both aesthetic and therapeutic purposes by modulating cutaneous inflammation, encouraging angiogenesis and enhancing collagen production.
Explanatory article about the documented benefits of photobiomodulation and FLE. The article points the advantages in acne, skin rejuvenation, and its potential as an alternative therapeutic option to conventional therapies.
Case study of a 49-year-old patient suffering from acne eruption induced by erlotinib treatment. After trying different oral and systemic treatments, the use of Kleresca® Acne Treatment reduced notably the severity of her acne.
Extension trial to evaluate the efficacy of the FLE system as well as the duration of response. The study confirmed the long duration of effect following treatment as well as excellent patient safety profile.
Book chapter that explains the clinical experience in the use of Kleresca® FLE therapy for the treatment of acne patients. The document explains also the efficacy and the patient satisfaction obtained in the clinic.
12-week clinical trial to evaluate the efficacy and safety of the FLE system in the treatment of moderate to severe acne vulgaris. The treatment was found to be efficacious and safe, with a sustained clinical response at 12 weeks for the management of moderate to severe facial inflammatory acne.
Patient with a 3-month history of papulopustular eruption result of granulomatous rosacea. Modest improvement was observed with topical systemic treatments. After Kleresca®, there was a significant improvement and no relapse after 6 months it was finalized.
Patients were treated with FLE in order to investigate the role in the treatment in targeting inflammation and erythema in rosacea subtypes 1, 2 and 3. Results proved FLE to be effective with an improvement in the skin texture of the patient.
Patient suffering from papulopustular rosacea receives FLE treatment. After 5 weeks, the patient showed a marked reduction of the inflammatory reaction and an overall improvement of the large-pored skin type.
Combination of Kleresca® FLE to intensify and demask underlying solar lentigines before targeting with laser therapy. Kleresca® FLE successfully intensifies solar lentigines, preparing the skin before and rejuvenating it after more invasive therapies.
The present study investigated the role of light polarization on biological effects of FLE, focusing on IL-6 expression from inflamed human dermal fibroblast (HDF) cells by using polarizing filters. The immunomodulatory impact of FLE was also investigated on a human ex vivo skin model.
In this study, the effect of FLE therapy in 18 patients with superficial and deep second-degree burns divided in 2 investigator-initiated trials (IITs) was evaluated. An ex vivo investigation on FLE wound healing mode on a human skin model was also performed.